Enhanced association of isomerase to red cell me brain microtubules

In a Hungarian family with triosephosphate isomerase (TPI; D-gll aldehyde-3-phosphate keto-isomerase, EC 5.3.1.1) deficiency, germ-line identical, but phenotypically differing compound hel zygote brothers (one of them with neurological disorder) have I identified with the same very low ( brother without neurological d der > normal control. This distinct microcompartmentation of mi proteins may be relevant in the development of the neurodeger tive process in TPI deficiency and in other, more common neurolo diseases.