Heat Shock Proteins and Pain

Introduction Pain, especially chronic pain, is a health issue affecting about one-third of the population all over the world. The sensitization of pain is highly associated with inflammatory responses to tissue damage and other harmful signals. The heat shock proteins (HSP) have been demonstrated to play central rolesin the inflammatory responses and pain via regulating the protein folding, maturation, activation, and degradation of proteins in varioussignal pathways. The objective of this chapter was to summarize the role of HSP in pain and pain drug-induced signal pathways and antinociception.