Determination of selected biomarkers can be used in monitoring oxidative stress in the course of chronic failure

Abstract The aim of the study was to assess oxidative stress biomarkers considering the simplicity of their determination, invasiveness of material collection and their specificity. The following oxidative stress markers were evaluated: malonyldialdehyde, thiobarbituric acid reactive lipid peroxidation products, prostaglandin F2alpha, nitric oxide derivatives, nucleic acid damage products, advanced oxidation protein products and gas components in exhaled air: nitric oxide, hydrocarbons, isoprene, ethane. Analysis of the selected biomarkers indicates the usefulness of the determination of prostaglandin F2alpha, nucleic acid damage products, advanced oxidation protein products and gas components in the exhaled air as oxidative stress biomarkers in patients with chronic renal failure.