New Acylated Phenolic Glycosides with ROS-ScavengingActivity from Psidium guajava Leaves

Reactive oxygen species and subsequent oxidative stress are reported to play important roles in chronic metabolic diseases. Plant-derived polyphenols, especially food-derived phenolics, have attracted a lot of attention due to their potential usage against oxidative stress-related diseases. The leaf of Psidium guajava (known as guava) is regarded as a good resource of polyphenols and its products are commercially available in Japan as functional foods against multiple chronic metabolism disorders. In the course of finding novel polyphenols with antioxidative activities from guava leaf, 11 acylated phenolic glycosides (1–11), including 5 new oleuropeic acid-conjugated phenolic glycosides, named guajanosides A–E (1, 2, and 5–7), along with 17 known meroterpenoides (12–28), were isolated and identified. Their structures were determined by spectroscopic data analysis, chemical degradation, and acid hydrolysis. Compounds 1, 2, and 5–11 displayed potent reactive oxygen species-scavenging activity in lipopolysac...