Expression of the Ca2+-ATPase SERCA2a (ATP2A2) Gene and the Ryanodine Receptor (RYR2) Gene in Patients with Chronic Heart Failure

The analysis of the relative expression of the Ca2+-ATPase SERCA2a gene (ATP2A2) and the ryanodine receptor (RYR2) gene in the myocardium of 85 patients with coronary artery disease complicated by heart failure, depending on the clinical picture of the disease, was performed. A decrease in the expression level of the ATP2A2 and RYR2 genes in patients with left ventricular hypertrophy was revealed. It was established that the expression level of the RYR2 gene decreased with the severity of the functional class of heart failure. A correlation was found between the expression level of the ATP2A2 gene and the echocardiography parameters.