Structural Diversity of Co(II) Coordination Polymers: Treatment Activity on Hypotension During Surgery by Blocking α Receptor on Peripheral Blood Vessels

Two Co(II)-based coordination polymers (CPs) with the molecular formulae of [Co4(5-mtz)4(l-mal)2(H2O)2]n (1, 5-mtz = 5-methyltetrazole, L-mal = L-malic acid) and {[Co8(S-mal)4(bptc)(H2O)12]·0.5H4bptc·7.5H2O}n (2, S-mal = S-malic acid, H4bptc = biphenyl-3,3′,5,5′-tetracarboxylic acid) were synthesized under a hydrothermal or solvothermal surrounding. The prepared two complexes have been determined through the powder and single crystal X-ray diffraction, thermogravimetric (TG) analyses and IR spectroscopy. To prevent the hypotension during surgery after injected with anesthetic, their biological activity was estimated in this research. The CCK-8 (Cell Counting Kit-8) assay was performed to measure the viability of the HUVEC cells after compounds treatment. The relative expression of the α receptor was evaluated by real time RT-PCR (reverse transcription-polymerase chain reaction). Besides, the blood pressure was measured as well.