Effect of naloxon on expression of c-fos mRNA in rat cerebral cortex

To investigate relationship between naloxon woke up anaesthetic rat by XFM and c-fos gene,by study on effect of naloxon on the expression of c-fos mRNA in the rat cerebral cortex,78 SD rats were divided randomly into blank control group,XFM group,XFM add naloxon group,XFM add saline group.The contents of c-fos mRNA was measured by RT-PCR in cerebral cortex.The contents of c-fos mRNA was obviously increased in the XFM anesthesia group as compared with blank control group(P0.01).The contents of c-fos mRNA was significantly decreased after naloxon administrated as compared with XFM group(P0.05 or P0.01).The results indicated that naloxon palinesthesia action was concerned with c-fos gene in cerebral cortex.Naloxon attenuates expression of c-fos gene in the rat cerebral cortex may be an important mechanism that naloxon woke up anaesthetic rat by XFM.