The Low-Density Lipoprotein Cholesterol Hypothesis: An Update

Catabolism of VLDL by lipoprotein lipase creates higher density particles including HDL, IDL, and LDL. Each LDL contains a single apoB and has a core made of esterified cholesterol. The primary transport for cholesterol in the body is via LDL. The main mechanism of clearance of LDL is via hepatic LDL-R.