Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition

Hiroshi Morikawa,Masaki Tomishima,Natsuko Kayakiri,Takanobu Araki,David Barrett,Souichirou Akamatsu,Satoru Matsumoto,Satoko Uchida,Toru Nakai,Shinobu Takeda,Katsuyuki Maki

Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition

2014

Hiroshi Morikawa
Masaki Tomishima
Natsuko Kayakiri
Takanobu Araki
David Barrett
Souichirou Akamatsu
Satoru Matsumoto
Satoko Uchida
Toru Nakai
Shinobu Takeda
Katsuyuki Maki

The synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition and significantly improved MIC against Candida parapsilosis and echinocandin resistant-Candida is described.

Keywords:

Aspergillus
Natural product
Antifungal
Aspergillus fumigatus
Echinocandin
Growth inhibition
Candida parapsilosis
Hypha
Biochemistry
Chemistry
candida spp
hyphal growth

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