Cannabidiol Discovery and Synthesis A Target‐Oriented Analysis in Drug Production Process

The current state of evidence and recommendations for cannabidiol (CBD) and its health effects change the legal landscape and aim to destigmatize its phytotherapeutic research. Recently, some countries have included CBD as an antiepileptic product for compassionate use in children with refractory epilepsy. The growing demand of CBD leads to the need for high purity cannabinoids for the emerging market. The discovery and development of approaches toward cannabidiol synthesis have arisen from the successful extraction of Cannabis plants for cannabinoid fermentation in brewer's yeast. To understand the different contributions to CBD synthesis and its key intermediates, design, and enhancement, we offer a detailed analysis of the history behind cannabinoid compounds and their optimization.