Combined Microscopy and Hyperelastic Warping for the Measurement of Intranuclear Mechanics in Native 3D Tissue

The cell nucleus directs the regulation of normal cellular functions as well as the expression of proteins required for adaption to environmental changes. Mechanical forces are an important determinant of gene expression, and yet the measurement of intranuclear mechanics (e.g. strain) in cells embedded within their native tissue in situ remains a challenge.Copyright © 2013 by ASME