Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene.

Aimin Li,Suehiro Sakaguchi,Ryuichiro Atarashi,Bhabesh C. Roy,Ryota Nakaoke,Kazuhiko Arima,Nobuhiko Okimura,Juraj Kopacek,Kazuto Shigematsu

Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene.

2000

Aimin Li
Suehiro Sakaguchi
Ryuichiro Atarashi
Bhabesh C. Roy
Ryota Nakaoke
Kazuhiko Arima
Nobuhiko Okimura
Juraj Kopacek
Kazuto Shigematsu

1. Mouse lines lacking prion protein (PrPC) have a puzzling phenotypic discrepancy. Some, but not all, developed late-onset ataxia due to Purkinje cell degeneration.

Keywords:

Exon
Gene expression
Peptide sequence
Gene
Ataxia
Purkinje cell
Knockout mouse
Molecular biology
Intron
Biology
PRNP
Messenger RNA

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