Inhibition von Heat-shock Protein 90 (Hsp90) mittels EC154, einem neuen synthetischen Hsp90 Antagonist, reduziert das Wachstum von humanen Magen- und Pankreaskarzinomzellen in vivo

Heat shock protein 90 (Hsp90) has been identified to be crucial for stability and functionality of oncogenic signaling molecules, including EGFR, Her-2, Akt, Erk, and various transcription factors. Here we investigated growth inhibitory effects of a novel synthetic Hsp90 inhibitor (EC154) in gastrointestinal cancers.