A NOVEL ROUTE TO PYRIMIDINE ISODIDEOXYNUCLEOSIDES VIA MICHAEL-TYPE ADDITION ON UNSATURATED MODIFIED SUGARS
1997
Abstract A short, stereocontrolled synthesis of isonucleosides is described. This approach is based on the Michael-Type addition of silylated uracil or thymine with an appropriate acceptor as pyranoside precursor. The alkylated products obtained allow carbonyl reduction, providing a straightforward way to prepare new sugar-modified nucleosides.
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