REGIONAL FEATURES OF INFLUENCE OF RISK FACTORS FOR CHRONIC NON­COMMUNICABLE DISEASES ON FORMATION OF POLYMORBID PATHOLOGY

Purpose. To study regional features of the association of frequency of occurrence and the magnitude of the indices of the main risk factors for chronic non-communicable diseases (RF CNCD) with the degree of transnosological polymorbidity (PM) in male residents of the Novosibirsk Region (NR) and Saha (Yakutia) Republic. Methods. The analysis of 10 187 medical records of patients with therapeutic profile (men), examined and treated in the clinic of the Federal Research Center for Fundamental and Translational Medicine, Novosibirsk was carried out. The index of transnosological polymorbidity was assessed by the number of nosological forms in accordance with the ICD-10. According to the clinical and laboratory examination, the following RF CNCD were assessed: high blood pressure, increased blood levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, uric acid, decreased blood level of low-density lipoprotein cholesterol, obesity. Results. Both among the residents of the NR and of the Yakutia, with an increase in the index of polymorbidity, there was an increase in the severity and frequency of occurrence of the studied RF CNCD. There was an increase in the frequency of occurrence in persons with high PM in comparison with those with a low degree of PM: arterial hypertension among residents of NR and of the Yakutia - by 2 times (p < 0.001), increase in total cholesterol in the blood among residents of the NR and of the Yakutia - by 1.2 times (p < 0.001, p = 0.003 respectively), obesity - for residents of the NR by 2.4 times, for residents of the Yakutia - by 1.7 times (p < 0.001), hyperglycemia - in residents of NR - by 2 times (p < 0.001), hyperuricemia - among residents of NR - by 1.5 times (p < 0.001). Conclusion. The role of some hemodynamic and metabolic risk factors of RF CNCD in the development of polymorbid pathology among residents of the regions of Siberia and the North has been established. The obtained data indicate the need to take into account the region of residence of such patients in the course of personalized prophylaxis with mandatory detection and correction of the modifiable RF CNCD.