Localization of the gene that codes for adenine phosphoribosyltransferase on the genetic map of chromosome 8 of mouse

Polymorphism of electrophoretic mobility of adenine phosphoribosyltransferase (APRT) was found in Mus musculus bactrianus, a population of domestic mouse. The presence of intraspecies polymorphism allows localization of the gene that codes for this enzyme on the genetic map of the 8th chromosome. Two markers were utilized to map the Aprt gene: the plasmin esterase-1, which is coded by the gene Es-1 located at a distance of 26 morganids from the centromere; and the Robertsonian translocation Rb(8.17)1 Iem, which marks the centromere. Results of the linkage analysis showed the gene Aprt to be located on the genetic map of the 8th chromosome at a distance of 51 morganids from the centromere and 25 morganids distil of the gene Es-1. Also discussed in this work was the influence of emotional stress on the recombination process in the 8th chromosome.