Glycosyl/MOF-5-based carbon nanofibers for highly sensitive detection of anti-bacterial drug quercetin

Abstract Glycosyl-functionalized metal organic framework-5 (Glycosyl/MOF-5) based porous carbon nanofibers (Glycosyl/MOF-5-CNFs) were synthesized using MOF-5 as a precursor and glucose as an additional carbon source. The cubic Glycosyl/MOF-5 nanoparticles and polyacrylonitrile suspensions were used to prepare nanofibers by using electrospinning. The as-prepared electrospun nanofibers were then carbonized at high temperatures under argon to prepare Glycosyl/MOF-5-CNFs. The obtained material was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption-desorption isotherms, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The electrochemical behavior of quercetin was studied using a glassy carbon electrode modified with Glycosyl/MOF-5-CNFs. Further, the influences of the modifier dosage, enrichment potential, enrichment time, and pH were investigated. Under optimal conditions, the linear responses for quercetin were in the ranges of 2.0 × 10−7–1.0 × 10−5 mol L − 1 and 1.0 × 10−5–2.0 × 10−4 mol L − 1 with a detection limit of 8.33 × 10−8 mol L − 1. The fabricated electrochemical sensor was successfully utilized for the determination of quercetin, with recoveries obtained between 95.5% and 100.2%.