Enhanced skin adhesive property of electrospun α-cyclodextrin/nonanyl group-modified poly(vinyl alcohol) inclusion complex fiber sheet

Many medical tapes on the market lack sufficient adhesive strength and breathability. Owing to its high biocompatibility, poly(vinyl alcohol) (PVA), a synthetic polymer, has attracted attention in the medical field. In this study, we aimed to prepare an inclusion complex fiber (ICFiber) using α-cyclodextrin (α-CD) and nonanyl-group-modified PVA (C9–PVA) for skin adhesion with improved performance. By changing the concentration of α-CD, six microfiber sheets were fabricated by electrospinning the α-CD/2.3C9–PVA inclusion complex solutions. The bonding strength and energy of the ICFiber sheets on the porcine skin were evaluated. Among the tested ICFiber sheets, the ICFiber-3 (molar ratio of α-CD/C9 groups was 0.612) sheet showed high tensile strength and break strain. The bonding strength and energy of ICFiber-3 sheet on porcine skin were 1.10 ± 0.11 N and 5.07 ± 0.94 J m−2, respectively, in the presence of water. In addition, ICFiber-3 sheet showed a better water vapor transmission rate (0.95 ± 0.02 mL per day) than commercial tapes. These results demonstrate that the α-CD/2.3C9–PVA ICFiber sheet is a promising adhesive for wearable medical devices.