Genealogy study of three generations of patients with bipolar mood disorder Type I..

Byline: Bahman. Salehi, Sara. Khoz, Bahman. Sadeghi, Manouchehr. Amanat, Mona. Salehi Introduction: The purpose of this research is genealogy examination of three generation of bipolar mood disorder Type I patients. Methods: Patients selected using Poisson sampling method from 100 patients with bipolar mood disorder Type I, referring to a psychiatric center of Amir Kabir Hospital of Arak, Iran. Examine issues such as physical ailments, psychological review of living and deceased family members of each patient, drawn family pedigree using pedigree chart, check the relationship of the different pattern of the autosomal dominant and recessive disease, sex-linked dominant and recessive and linked to Y chromosome have been performed on patients. Different methods used in this study are pedigree chart and young mania rating scale and SPSS and Pearson's correlation test for analyzing the data collected. Results: Among the studied inheritance patterns, the most common inheritance pattern was autosomal recessive. There was a significant relationship between age, number of generation, and inheritance patterns with physical ailments in families of patients with bipolar mood disorder (P 0.05). Furthermore, there was a significant relation between generation and skin, gastrointestinal, ovarian, lung, coronary heart disease, diabetes mellitus, hypertension, Cerebrovascular accident (CVA), hyperlipidemia, cardiomyopathy, hypothyroidism, and kidney disease in patients with bipolar affective disorder Type I (P Introduction Bipolar mood disorder Type I is a complex psychiatric disease that characterized by repeated episodes of depression and mania or hypomania. This disorder with its recurrent nature could be recurred or became chronic so that on the basis of some researches, the symptoms of this disorder does not recur in only 7% of cases.[sup][1],[2],[3] The onset of bipolar mood disorder Type I has been typically reported in late adolescence or early adulthood with a period of depression after one or more cycles of depression with the occurrence of mania.[sup][2],[4],[5],[6] It is worth noting that not much information available in terms of the prevalence of bipolar mood disorder Type I in Iran, but Mohammadi et al .[sup][7] reported the prevalence rates of bipolar disorder Type I and Type II about 1.0%–7.0% over the lifetime of Iranian adult population generally. Prevalence of bipolar depression in Iran has been reported 1% during 2011–2012 by Radgoudarzi et al .[sup][7],[8],[9] Many research linked the causes of bipolar depression to environmental and biological factors; for example, some studies have shown that people with certain genes are more likely to develop bipolar disorder [sup][8],[9],[10],[11] and children with a family history of bipolar disorder are more at risk for this disorder than children who do not have this history.[sup][10],[12],[13],[14] As well as environmental stressors, inflammatory disorders, and immune system changes (the level of preinflammatory cytokines such as interleukin [IL]-1 and tumor necrosis factor alpha and some anti-inflammatory and regulatory cytokines such as IL-4, and 10 in people with bipolar disorder is significantly higher than healthy people), the volume loss of anterior cingulate gyrus, particularly gray matter, and decreased activity of orbitofrontal cortex and anterior cingulate are the other causes besides genetic factors that have been considered by researchers as causal factors for bipolar depression.[sup][12],[15],[16],[17],[18] Finally, since various studies have been shown the strong genetic influence in the pathophysiology of bipolar disorder, it seems that further research among various races and communities, particularly in genetic relation to other diseases, could considerably help faster and more effective treatment of patients with this disorder, and so, this study aimed to survey the pedigree of three generations of patients with bipolar mood disorder Type I. …