Palladium-Catalyzed C12-Selective Direct Arylation of [1,2-c] Quinazolin-6(5H)-ones

A straightforward approach to the synthesis of the challenging 12-arylindolo[1,2- c ]quinazolin-6(5 H )-ones through the palladium-catalyzed direct arylation of N -benzyl and NH-free [1,2- c ]quinazolin-6(5 H )-ones with aryl halides is described.