Progress in study of exercise, monocarboxylate transporter 1 and lactic shuttle

Study have already discovered that the monocarboxylate transporter family (MCTs) has now fourteen members of MCTs, the MCT1 organization distribute very breadth, distribute particularly in muscle fiber of oxidize the type. The MCT1 content and mitochondrial densities are related very well. The MCT1 and MCT4 carry out “Cell-cell” and “intracellular lactate shuttle” in the cells to wear the shuttle together, delivering to have the special function for the lactic acid. The researchers think that the MCT1 belongs to one of the choice metabolism gene, adjusting in exercising to stimulate ascends very quickly and the muscle contracting increased proper activity of MCTs. It is proposed that MCT1 expression may be important for blood lactate removal after supramaximal exercise based on the existence of lactate shuttles and, in turn, in favor of a better tolerance to muscle fatigue. Exercise increasing the translation efficiency of the MCT1 and the stability of protein, that make MCT1 of change also is complicated, not only depend on the sport accumulate quantity, but also depend on the athletic stage. The meaning lies in the MCT1 of up adjust with sport train combine to guide the training. [Life Science Journal. 2007; 4(3): 57 – 63] (ISSN: 1097 – 8135).