Simultaneous spectrophotometric estimation of valdecoxib and paracetamol in tablet formulations

A simple, accurate, economical, and reproducible method for simultaneous estimation of valdecoxib and paracetamol in two-component tablet formulation has been developed. The method of analysis is derivative spectroscopy to eliminate spectral interference by measuring absorbances at two wavelengths 284 nm and 301 nm for valdecoxib and paracetamol respectively. The results obtained in triplicate were validated statistically and by recovery studies.