Three-component [3+2+1]heteroannulation for the synthesis of 1,3,5-triazine derivatives
2015
Using ethane-1 ,2-diol as solvent and Cs2 CO3 as base promoter,a series of 1,3,5-triazine derivatives were synthesized via a three-component reaction of aryl carboximidamide and aldehydes with the the ratio of amount of substance 2∶1 under microwave irradiation.This method has the advantages of short reaction times (22~30 min), simple operation and environment friendliness.The structures of the products were identified by IR,1 HNMR and HRMS.Furthermore,the compound 2-(4-methylphenyl)-4,6-diphenyl-1,3,5-triazine was confirmed by X-ray dif-fraction.
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