RuCl3-Catalyzed Regioselective Diarylation with Aryl Tosylates via C-H Activation

Abstract The direct arylation of arylpyridines with aryl tosylates was carried out smoothly in the presence of 2.5 mol% RuCl3 using MesCOOH as crucial promoter to generate biarylated products. The method is simple, efficient, safe, and regioselective, can be performed in the absence of expensive ligands, and does not require any precautions with regard to the exclusion of air and moisture. The biarylated products were obtained in good yields. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.