Notch post-translationally regulates β-catenin protein in stem and progenitor cells
2011
Srivastava and colleagues find that membrane-bound Notch associates with and negatively regulates active β-catenin in embryonic stem cells, cardiac progenitors and colon cancer cells. This ligand-independent effect of Notch requires the endocytic adaptor protein Numb and targeting of β-catenin to lysosomes.
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