Chapter 13:SIRT1 Activators in Development

The sirtuins are a family of seven evolutionarily conserved enzymes that require the co-factor nicotinamide adenine dinucleotide (NAD+) and primarily catalyze the deacetylation and ADP-ribosylation of e-acetyl-Lys residues in protein substrates.1–3 Interest in these enzymes stems from the roles they...