Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA

Carrie Rocca,Sean Dennin,Yongli Gu,Joohwan Kim,Samantha Chigas,Diana Najarian,Saeho Chong,Shannon Gutierrez,James Butler,Klaus Charisse,Gabriel J. Robbie,Yuanxin Xu,Kirk Brown

Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA

2019

Carrie Rocca
Sean Dennin
Yongli Gu
Joohwan Kim
Samantha Chigas
Diana Najarian
Saeho Chong
Shannon Gutierrez
James Butler
Klaus Charisse
Gabriel J. Robbie
Yuanxin Xu
Kirk Brown

Aim: The electrophoretic mobility shift assay (EMSA) was evaluated as an alternative to ultrafiltration (UF) to assess plasma protein binding (PPB) of small interfering RNAs (siRNA) and antisense o...

Keywords:

Chromatography
Electrophoretic mobility shift assay
Sense (molecular biology)
Chemistry
RNA interference
Plasma protein binding
Small interfering RNA
Ultrafiltration
Oligonucleotide
antisense oligonucleotide
Biochemistry

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