Induction of sister-chromatid exchanges by alcohol and alcoholic beverages after metabolic activation by rat-liver homogenate.

Abstract Samples of alcohol and alcoholic beverages induced SCEs in Chinese hamster ovary cells in the presence of rat-liver homogenate for metabolic activation. SCE tests with acetaldehyde, and measurement of acetaldehyde concentration in tests with alcohol, indicate that SCE induction by alcohol is caused by formation of acetaldehyde.