Chisomicines A-C, limonoids from Chisocheton ceramicus.

Ibrahim A. Najmuldeen,A. Hamid A. Hadi,Khalijah Awang,Khalit Mohamad,Kamal Aziz Ketuly,Mat Ropi Mukhtar,Soon-Lim Chong,Gomathi Chan,Mohd Azlan Nafiah,Ng Seik Weng,Osamu Shirota,Takahiro Hosoya,Alfarius Eko Nugroho,Hiroshi Morita

Chisomicines A-C, limonoids from Chisocheton ceramicus.

2011

Ibrahim A. Najmuldeen
A. Hamid A. Hadi
Khalijah Awang
Khalit Mohamad
Kamal Aziz Ketuly
Mat Ropi Mukhtar
Soon-Lim Chong
Gomathi Chan
Mohd Azlan Nafiah
Ng Seik Weng
Osamu Shirota
Takahiro Hosoya
Alfarius Eko Nugroho
Hiroshi Morita

Three new limonoids, chisomicines A―C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.

Keywords:

Stereochemistry
Viability assay
Triterpene
Bark
Meliaceae
Two-dimensional nuclear magnetic resonance spectroscopy
Terpenoid
Chisocheton ceramicus
Pharmacognosy
Biology

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