Separation of Basic Drug Enantiomers by Capillary Electrophoresis with New Glycosaminoglycan.

A new fucose-containing glycosaminoglycan was investigated as the chiral additive for the separation of basic drug enantiomers by capillary electrophoresis. Tolperisone and eperisone enantiomers were not separated with α- or β-cyclodextrin, or heparin as the chiral additive, but were separated with the new fucose-containing glycosaminoglycan. A variety of basic drug enantiomers were resolved using 2-5%(w/w) solution of the glycosaminoglycan in 10 mM phosphate buffer (final pH 5.0).