Enhanced Collagen Formation in Mice with Controlled Release of Frozen-Pooled Platelet-Derived Factors

Platelet-derived factors messenger to regulate a wel-orchestrated and complex series of events involving cel-cel and cel-matrix interactions and play a key role during the various phases of the wound-repair process.To evaluate the effects of controled release of platelet-derived factors,we performed the subcutaneous implantation of gelatin hydrogel loaded with frozen-pooled platelet-rich plasma into the back of mice. Consequently,a successful enhancement of colagen formation was observed at the subcutaneous tissues on day 14.The present study reveals that this novel therapeutic approach is hopeful to improve the recovery of healing-impaired cutaneous wound.