CALCITONIN GENE-RELATED PEPTIDE IS AN INHIBITOR OF ALDOSTERONE SECRETION

Abstract This study examined the effects of calcitonin gene-related peptide (CGRP) on aldosterone secretion both in vivo and in vitro. Intravenous administration of CGRP (0.01 ug/kg) in 6 conscious dogs produced a significant decrease in plasma aldosterone concentration from 68 + 12 pg/ml to 28 + 1 1 pg/ml(p<0.05) despite a mild but significant elevation of plasma renin activity. In an in vitro study using isolated rabbit adrenal glomerulosa cells CGRP reduced the basal aldosterone secretion in a dose-related manner and furthermore 10−9 M CGRP inhibited the aldosterone secretion stimulated by 10−8 M angiotensin II.From these results it is suggested that CGRP has an inhibitory effect on aldosterone secretion.