Nucleophilic Hydroxymethylation by the (Isopropoxydimethylsilyl)methyl Grignard Reagent: 1‐(Hydroxymethyl)cyclohexanol from Cyclohexanone

Nucleophilic hydroxymethylation by the (isopropoxydimethylsilyl)methyl Grignard reagent: 1-(hydroxymethyl)cyclohexanol from cyclohexanone reactant: (isopropoxydimethylsilyl)methyl chloride (16.67 g, 100 mmol) intermediate: 1-[(isopropoxydimethylsilyl)methyl]cyclohexanol product: 1-(hydroxymethyl)cyclohexanol Keywords: addition, to CO; Grignard and related reactions; metalation reactions, magnesium; oxidation, miscellaneous; replacement reactions, halogen by oxygen; tetrahydrofuran; peroxides, detection; peroxides, disposal