Efficient Killing of Multidrug-Resistant Intracellular Bacteria by AIEgens in Vivo
2020
Bacteria infected cells
acting as “Trojan horses” not only protect bacteria from antibiotic therapies
and immune clearance, but also increase the dissemination of pathogens from the
initial sites of infection. Antibiotics are hard and insufficient to treat such
hidden intracellular bacteria, especially the multidrug-resistant (MDR) bacteria. Herein, aggregation-induced
emission luminogens (AIEgens) such as TBPs showed potent broad-spectrum
bactericidal activity against both extracellular and intracellular Gram-positive
pathogens at low-dose levels. TBPs triggered
reactive oxygen species (ROS)-mediated membrane damage to kill bacteria, regardless of light
irradiation. Additionally, such AIEgens activated mitochondria dependent
autophagy to eliminate intracellular bacteria in host cells. Compared to the
routinely used vancomycin in clinics, TBPs showed comparable efficacy against
methicillin-resistant Staphylococcus aureus (MRSA) in vivo. Our
studies demonstrate that AIEgens are promising new agents for the treatment of
MDR bacteria associated infections.
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