Synthesis and Biological Activity of 2′,5′-Oligoadenylate Trimers Containing 5′-Terminal 5′-Amino-5′-deoxy- and 5′-Amino-3′,5′-dideoxyadenosine Derivatives
1999
Abstract Some new 2′,5′-oligonucleotide trimers containing 5′-terminal 5′-amino-5′-deoxy- and 5′-amino-3′,5′-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT),HIV-1 induced syncytia formation and PCR amplification.
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