Five-membered heterocyclic compound, preparation method therefor, pharmaceutical composition and use

Provided are a five-membered heterocyclic compound, a preparation method therefor, a pharmaceutical composition and a use. Specifically, provided is a compound having formula (I), the definitions of the various groups being laid out in the description. The compound having formula (I) has an effect of inhibiting tubulin activity, and may be used to prepare a drug treating or preventing mammalian diseases related to tubulin regulation abnormalities.