Stimulatory Effect of Epinephrine on Biofilms of Micrococcus luteus C01

This is the first report on biofilm formation by Micrococcus luteus C01 in model systems stimulated by epinephrine. In the presence of 900 pg/mL of epinephrine in the medium, a 52.3% increase in the metabolic activity of biofilm bacteria compared to the control (without epinephrine). However, after 72 h of growth, the total amount of biofilm biomass in the presence of epinephrine increased by 89.5%, while bacterial metabolic activity in the biofilm remained at the control level. It may be assumed that the targets of the stimulating effect of epinephrine are some pathways of bacterial metabolism, which determine both their growth (at the initial stages of biofilm development) and synthesis of the biofilm matrix, which is more pronounced in mature biofilms.