Effets isotopiques secondaires du deuterium dans l'hydrolyse de l'acétal mixte dérivé du benzaldehyde de l'éthanol et du phénol

The secondary kinetic deuterium isotope effect has been measured for the general acid-catalysed hydrolysis of benzaldehyde ethyl phenyl acetal (1). It has been found that this α isotope effect increases from 1.06 (H3O+) to 1.26 (H2O), when the strength of the acid catalyst decreases. The significance of this finding is discussed.