Formulation, development and evaluation of mouth melting tablet of famotidine by using natural and synthetic superdisintegrants

The Purpose of the present research was to prepare mouth melting tablet of Famotidine by using natural and synthetic superdisintegrants such as, ispaghula husk powder, croscarmilose, crospovidone .  the objective to reduced patient compliance and the reduced onset action of due to fast pass metabolism. Tablets prepared by direct compression method. The powder mixtures prepared to both pre and post compression evaluation parameters such as micromeritics properties, tablets hardness, friability , wetting time , disintegration time and in –vitro drug release . The results of both pre and post formulations were of acceptable to good flow ability and in-vitro release determine different model viz. zero order, first order, Hixson-Crowell equation, Higuchi model & Korsmeyer-peppas model indicate that formulation F3 found to be the best fit Korsmeyer-peppas model.