The role of superoxide dismutase (SOD) in skin disorders

Environmental stress factors attack body cells daily. As skin is the first barrier to exogenous threats, such as UV exposure, chemicals and pathogens, a proper strategy to prevent skin inflammation is necessary. As the environment tends to strip away the nutrients essential to maintain the skin’s hydrolipidic barrier, restoration of the skin’s natural antioxidant balance seems to be an alternative and convenient method to maintain healthy skin. At the moment, many studies have considered superoxide dismutase (SOD) as a good agent for the prevention or the therapeutic treatment of skin inflammation. Therefore, we will discuss the mechanism of action of SOD in numerous skin disorders and evaluate whether the use of a powerful antioxidant like SOD B can help deliver benefits against skin alterations.