Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1α

Purpose Chemoresistance severely restricts the anti-cancer medicines from effectively treating human ovarian cancer, which has been shown to develop and survive in the specific hypoxic environments. To understand the relationship between hypoxia and chemoresistance, we investigated the potential role of hypoxia in the pathophysiology of chemoresistance, especially focusing on hypoxia-inducible factor 1α (HIF-1α).