Brefeldin-A: an Antiproliferative Metabolite of the Fungus Curvularia trifolii Collected from the Veracruz Coral Reef System, Mexico

In this paper the isolation and structure analysis of three sterols and brefeldin-A from the mycelial extract of the liquid fermentation of fungus Curvularia trifolii isolated from the marine sponge Amphimedon compressa collected from the Coral Reef System of Veracruz is reported. This is the first report on the production of brefeldin-A by the fungus C. trifolii . The results on isolation biological activity support the importance of the conservation of the Mexican ecosystems of coral reefs as a source of microorganisms with a pharmaceutical potential.