High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction
2015
Background
Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to assay blood DNA methylation at approximately 4.5 million loci, each comprising 2.9 CpGs on average, in 697 normal subjects. Methylation measures at each locus are tested for association with approximately 4.5 million single nucleotide polymorphisms (SNPs) to exhaustively screen for methylation quantitative trait loci (meQTLs).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
69
References
88
Citations
NaN
KQI