Additional file 7: of Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition

Cédric Leroy,Pedro Ramos,Karen Cornille,Debora Bonenfant,Christine Fritsch,Hans Voshol,Mohamed Bentires-Alj

Additional file 7: of Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition

2016

Cédric Leroy
Pedro Ramos
Karen Cornille
Debora Bonenfant
Christine Fritsch
Hans Voshol
Mohamed Bentires-Alj

is a figure showing that p110β activation does not correlate with loss of PTEN. Immunoblots of lysates from parental and resistant cells treated for 24 hours as indicated. BYL719 (IC90) and AEW541 (1 μM). (PDF 140 kb)

Keywords:

Protein kinase B
PI3K/AKT/mTOR pathway
PTEN
Insulin-like growth factor 1 receptor
Cancer research
Chemistry

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