The Effects of Methylphenidate on Transcranial Magnetic Stimulation Parameters in Children with Attention Deficit Hyperactivity Disorder

Amac: Bu cal›flman›n amac›, dikkat eksiklii hiperaktivite bozukluu (DEHB) olan cocuklarda metilfenidat›n (MPH) tedavi oncesi ve sonras› transkranial magnetik stimulasyon (TMS) parametreleri uzerine etkisini incelemektir. Yontem: Yafllar› 7 ila 13 aras›nda deiflen, 24 DEHB olan er- kek cocukta MPH tedavisi oncesi ve sonras›nda kontrlateral sessiz period (CSP), servikal latans (CL), istirahat motor efli- ¤i (RMT) ve santral motor iletim zaman› (CMCT) olcumleri yap›lm›flt›r. Bulgular: MPH tedavisi CMCT'de anlaml› bir azalmaya yol acm›flt›r (p .05). Conclusions: The central motor conduction time (CMCT) includes the times of excitation, information processing of cortical cells, and axonal conduction time via corticospinal tract. Since MPH can not affect the axonal myelination such a short time, and since MPH did not affect CL, we speculate that the decrease in the CMCT may be imputed to increased information processing of cortical cells following MPH administration. Although previous studies suggested that information processing may be increased by MPH, further studies are warranted invastigating relationship between information processing and CMCT under the effect of MPH effect.