Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists

Abstract On the basis of the previously reported benzimidazole 1,3′-bipyrrolidine benzamides ( 1 ), a series of related pyrrolidin-3-yl- N -methylbenzamides were synthesized and evaluated as H 3 receptor antagonists. In particular, compound 32 exhibits potent H 3 receptor binding affinity, improved pharmaceutical properties and a favorable in vivo profile.