Institutional report - Experimental Sustained release of vancomycin from a new biodegradable glue to prevent methicillin-resistant Staphylococcus aureus graft infection

2010 
Prosthetic graft infection with methicillin-resistant Staphylococcus aureus (MRSA) is one of the most serious complications of cardiovascular surgery. Seeking to prevent graft infection, we evaluated the efficacy of a new biodegradable hydrogel glue (new-glue) composed of aldehyded dextran and ´-poly(L-lysine) which acts as a local sustained-release carrier of vancomycin. Rats (ns40) were implanted with 1-cm Dacron grafts in the subcutaneous pockets. Groups (ns10 each) were as follows: no treatment (group A), topical vancomycin solution 2 and cultured. The quantity of MRSA was significantly lower in group D than in the other groups (P-0.0001). About 95% of the total vancomycin was released from the new-glue over the 72 h experimental period, and the tissue concentration of vancomycin remained above the minimum inhibitory concentration for the MRSA strain throughout the experiment. This new vancomycin-containing glue effectively prevented prosthetic graft infection and thus may be a promising biodegradable drug vehicle. 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
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