Flavonoids isolated from Sinopodophylli Fructus and their bioactivities against human breast cancer cells

Abstract Four prenylated flavonoids compounds 1 – 4 , named sinopodophyllines A–D, and a flavonoid glycoside (compound 13) , sinopodophylliside A, together with 19 known compounds (compounds 5 – 12 and 14 – 24) were isolated from the fruits of Sinopodophyllum hexandrum . The structures of new compounds were elucidated by extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compounds 1 – 6, 9 – 11, and 14 – 17 were tested for their cytotoxicity against human breast-cancer T47D, MCF-7 and MDA-MB-231 cells in vitro , and compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC 50 values −1 ) against T47D cells.