Baoyuan jieyu formula ameliorates depression-like behaviour in rats induced by simulated long-term spaceflight composite stress through regulating MAPK and BDNF pathways

Abstract During space flight, astronauts are exposed to various influences of extreme environments and susceptible to develop depression-like behavior. Thus, this study aims to explore the molecular biological mechanism of the cause of depression-like behavior and reveal the effect of Baoyuan Jieyu Formula (BYJYF) on ameliorating depression-like behavior. Here, rats exposed to simulated long-term spaceflight composite stress (LSCS) reduced the sucrose preference rate (P