Photobodies: lichtaktivierbare Einzeldomänen-Antikörper

Photobodies are light-activatable single domain antibody fragments which show up to several-thousand fold impaired binding affinity in their photo-caged state. By irradiation with light, they regain their native antigen binding capacity. The endowed temporal and spatial control of photobodies over the binding event is expected to enable manifold potential applications in basic research, diagnostics and therapy.